Sequence2Script is a tool to assist laboratories and clinicians with translating pharmacogenomic testing results into clinically useful recommendations. The recommendations produced by this tool are based on expert guidelines developed by the Clinical Pharmacogenetics Implementation Consortium (CPIC) and the Royal Dutch Association for the Advancements of Pharmacy - Pharmacogenetics Working Group (DPWG).
Genes Supported
ABCG2
CYP2B6
CYP2C19
CYP2C9
CYP2D6
CYP3A5
DPYD
F2
F5
HLA-A
HLA-B
NUDT15
SLCO1B1
TPMT
UGT1A1
VKORC1
Key Features
User-friendly: The Sequence2Script tool uses drop down menus and radio buttons to improve user satisfaction with the software and reduce input errors.
No "black box' algorithms: Recommendations are based directly on guidelines developed by international expert groups (e.g. CPIC, DPWG) and FDA drug labels.
Clinically relevant: The tool not only interprets gene-drug interactions but also has the capability to account for well-established drug-drug-gene interactions.
Current Version
Visit sequence2script.com
Development Team
Tony Cheng
Ankita Narang
Ziad Al Bkhetan
Patrick Wu
Jose Nicolas Mora
Elzanne Venter
Citation Information
Bousman CA, Wu P, Aitchison KJ, Cheng T. (2021). Sequence2Script: A web-based tool for translation of pharmacogenetic data into evidence-based prescribing recommendations. Frontiers in Pharmacology.